Now showing items 1-4 of 4

  • Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. 

    Barron, Gemma A.; Goua, Marie; Kuraoka, Isao; Bermano, Giovanna; Iwai, Shigenori; Kong Thoo Lin, Paul (Elsevier http://dx.doi.org/10.1016/j.cbi.2015.10.017, 2015-12-05)
    BARRON, G. A., GOUA, M., KURAOKA, I., BERMANO, G., IWAI, S. and LIN, P. K. T. L., 2015. Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. Chemico-Biological Interactions, Vol 242, pp. 307-315.
    Bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM) bisintercalates to DNA and is a potential anti-cancer therapeutic. In an attempt to elucidate the mechanism(s) underlying the potential of BNIPDaCHM; earlier ...
  • Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. 

    Kopsida, Maria; Barron, Gemma A.; Bermano, Giovanna; Kong Thoo Lin, Paul; Goua, Marie (Royal Society of Chemistry https://dx.doi.org/10.1039/C6OB01850E, 2016-09-21)
    KOPSIDA, M., BARRON, G.A. BERMANO, G., KONG THOO LIN, P. and GOUA, M. 2016. Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. Organic and biomolecular chemistry [online], Advance Articles. Available from: https://dx.doi.org/10.1039/C6OB01850E
    Bisnaphthalimidopropyl (BNIP) derivatives are a family of compounds that exert anti-cancer activities in vitro and, according to previous studies, variations in the linker sequence have increased their DNA binding and ...
  • Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. 

    Barron, Gemma A. (The Robert Gordon University School of Pharmacy and Life Sciences, 2010-06)
    The synthesis and characterisation of novel bisnaphthalimidopropyl polyamine (BNIPP) derivatives, has gained pace over the last couple of years, as they have enhanced aqueous solubility, without loss of biological activity, ...
  • Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes. 

    Al Ali, Fatima Mohamed (Robert Gordon University Faculty of Health and Social Care. School of Pharmacy and Life Sciences., 2016-01)
    AL ALI, F.M. 2016. Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes. Robert Gordon University, MRes thesis.
    Diabetes mellitus (DM) is the most common metabolic disease worldwide. This condition accounts for the majority of renal failure and blindness in adult’s aged between 20 to 74 years of age. After 20 years, some of type 1 ...