Now showing items 1-4 of 4

  • Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins. 

    Dospinescu, Ciprian (The Robert Gordon University School of Pharmacy and Life Sciences, 2009-03)
    DOSPINESCU, C. and CRUICKSHANK, S. F., 2006. [cL-]o and [Ca2+]o affect hypoxia-induced contractions differently in porcine intrapulmonary arteries and veins. In: Abstracts, The Physiological Society workshop on Cardiopulmonary Function in Health and Dieease, Prague, The Czech Republic)
     
    DOSPINESCU, C. and CRUICKSHANK, S. F., 2006. Cl- channel blocker NFA inhibits PGF2a and hypoxia-induced contractions in porcine intrapulmonary veins but not in arteries. In: Absrracts, FASEB Summer Research Conference, Smooth Muscle, Snowmass Village, Colorado, USA.
     
    DOSPINESCU, C., MCCAIG, D., WAINWRIGHT, C. L. and CRUICKSHANK, S. F., 2006. Different role for [Cl-]o in hypoxia induced contractions of small intrapulmonary arteries and veins. In: Journal of Molecular and Cellular Cardiology, 40 (6), pp. 1015.
     
    DOSPINESCU, C., YAMAWAKI, N., MCCAIG, D., WAINWRIGHT, C. L. and CRUICKSHANK, S. F., 2005. Low chloride potentiation of hypoxic pulmonary vasoconstriction. In: Journal of Physiology 568P:PC44.
     
    In the pulmonary circulation, alveolar hypoxia contributes to blood flow regulation. Hypoxic pulmonary vasoconstriction (HPV) involves both pulmonary arteries and veins, but little is known of the contractile mechanisms ...
  • Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells. 

    Weidmann, Anita Elaine (Robert Gordon University School of Pharmacy and Life Sciences, 2008-03)
    Chronic complications of diabetes mellitus are a pathological consequence of unregulated levels of blood glucose leading to disorders of the vascular system. When investigating the vascular complications the changes in ...
  • Studies investigating the mechanisms of the cardioprotective effects of Cannabidiol. 

    Hepburn, Claire Y. (Robert Gordon University School of Pharmacy and Life Sciences., 2014-05)
    The phytocannabinoid cannabidiol (CBD) has a complex pharmacology which is thought to include, but is not limited to, an ability to act as an inverse agonist at the CB1 and CB2 receptors and an antagonist of GPR55. Moreover, ...
  • Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. 

    Skene, Karen E. (The Robert Gordon University School of Pharmacy and Life Sciences., 2010-04)
    MARKOS, R., RUANE-O'HORA, T., SNOW, H. M., KELLY, R., WAINWRIGHT, C. L., SKENE, K., DRAKE-HOLLAND, A. J. and NOBLE, M. I., 2008. Dilation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig. Acta Physiologica, 194, pp. 207-213.
     
    SKENE, K., CRUICKSHANK, S., KNOTT, R., PERTWEE, R. and WAINWRIGHT, C. L., 2009. Studies on endocannabinoids and neointimal proliferation in an in vitro murine model. Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference 2009, 29, pp. e9-e130.
     
    SKENE, K., HECTOR, E., CRUICKSHANK, S., PERTWEE, R. and WAINWRIGHT, C. L., 2008. Characterisation of the response produced by AEA in the murine carotid artery and effects of cannabinoids on ERK1/2 phosphorylation. 18th Annual Symposium of the International Cannabinoid Research Society, p. 87.
     
    SKENE, K., STEWART, C., MIDDLETON, D., PERTWEE, R. and WAINWRIGHT, C. L., 2006. Studies on the receptors mediating relaxant responses to the endocannabinoid anandamide in the porcine coronary artery. 16th Annual Symposium of the International Cannabinoid Research Society, p. 173.
     
    Neointimal formation is a complex process that occurs due to the over compensatory healing response produced by the vessel following injury. Three key events, SMC proliferation, SMC migration and the inflammatory response, ...