Now showing items 2-6 of 6

  • Hypoxia-induced responses of porcine pulmonary veins. 

    Arnold, Amy (Robert Gordon University School of Pharmacy and Life Sciences, 2017-01-01)
    ARNOLD, A. 2017. Hypoxia-induced responses of porcine pulmonary veins. Robert Gordon University, PhD thesis.
    The pulmonary vein (PV) constricts to hypoxia however little is known about the underlying mechanisms. Hypoxic PV constriction is proposed to recruit upstream capillary beds and optimise gas exchange in healthy humans and ...
  • Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells. 

    Weidmann, Anita Elaine (Robert Gordon University School of Pharmacy and Life Sciences, 2008-03)
    Chronic complications of diabetes mellitus are a pathological consequence of unregulated levels of blood glucose leading to disorders of the vascular system. When investigating the vascular complications the changes in ...
  • Studies investigating the mechanisms of the cardioprotective effects of Cannabidiol. 

    Hepburn, Claire Y. (Robert Gordon University School of Pharmacy and Life Sciences., 2014-05)
    The phytocannabinoid cannabidiol (CBD) has a complex pharmacology which is thought to include, but is not limited to, an ability to act as an inverse agonist at the CB1 and CB2 receptors and an antagonist of GPR55. Moreover, ...
  • Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. 

    Skene, Karen E. (The Robert Gordon University School of Pharmacy and Life Sciences., 2010-04)
    Neointimal formation is a complex process that occurs due to the over compensatory healing response produced by the vessel following injury. Three key events, SMC proliferation, SMC migration and the inflammatory response, ...
  • Use of a three dimensional porcine retinal explant model to detect HIF1 alpha for understanding diabetic retinopathy. 

    Iwuagwu, Benedicta; Cruickshank, Stuart F.; Rowe, Iain; Knott, Rachel M. (ASBMB https://www.asbmb.org/meeting2017/, 2017-04-22)
    IWUAGWU, B.U., CRUICKSHANK, S.F., ROWE, I. and KNOTT, R.M. 2017. Use of a three dimensional porcine retinal explant model to detect HIF1 alpha for understanding diabetic retinopathy. Presented at the American Society for Biochemistry and Molecular Biology annual meeting (ASBMB 2017), 22-26 April 2017, Chicaco, USA.
    Diabeticretinopathy (DR) is a major microvascular complication associated with diabetes mellitus and is a leading cause of blindness. Hypoxia and hyperglycemia are suggested to play crucial pathophysiological roles, but ...