Now showing items 2-5 of 5

  • Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. 

    Barron, Gemma A.; Goua, Marie; Kuraoka, Isao; Bermano, Giovanna; Iwai, Shigenori; Kong Thoo Lin, Paul (Elsevier http://dx.doi.org/10.1016/j.cbi.2015.10.017, 2015-12-05)
    BARRON, G. A., GOUA, M., KURAOKA, I., BERMANO, G., IWAI, S. and LIN, P. K. T. L., 2015. Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. Chemico-Biological Interactions, Vol 242, pp. 307-315.
    Bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM) bisintercalates to DNA and is a potential anti-cancer therapeutic. In an attempt to elucidate the mechanism(s) underlying the potential of BNIPDaCHM; earlier ...
  • Can selenium supplementation modify oxidative stress in-vitro? A role for selenium supplementation in the prevention of cardiovascular disease. 

    Leighton, Dean; Goua, Marie; Dolan, Eimear; Burgess, Katherine; Bermano, Giovanna (BioMed Central http://www.journal-inflammation.com/content/12/S1/P7, 2015-04)
    LEIGHTON, D., GOUA, M., DOLAN, E., BURGESS, K. and BERMANO, G., 2015. Can selenium supplementation modify oxidative stress in-vitro? A role for selenium supplementation in the prevention of cardiovascular disease. Journal of Inflammation, 12 (Suppl. 1), p.7.
    Two thirds of the UK population are either overweight or obese (body mass index (BMI) 25-29.9 and >30 kg/m2 respectively) and are typically characterised by systemic oxidative stress (OS); deemed to play a key role in ...
  • Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. 

    Kopsida, Maria; Barron, Gemma A.; Bermano, Giovanna; Kong Thoo Lin, Paul; Goua, Marie (Royal Society of Chemistry https://dx.doi.org/10.1039/C6OB01850E, 2016-09-21)
    KOPSIDA, M., BARRON, G.A. BERMANO, G., KONG THOO LIN, P. and GOUA, M. 2016. Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. Organic and biomolecular chemistry [online], Advance Articles. Available from: https://dx.doi.org/10.1039/C6OB01850E
    Bisnaphthalimidopropyl (BNIP) derivatives are a family of compounds that exert anti-cancer activities in vitro and, according to previous studies, variations in the linker sequence have increased their DNA binding and ...
  • Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid - possible role for endocannabinoids? 

    Michel, Lisa (Robert Gordon University School of Pharmacy and Life Sciences, 2012-05)
    The ω-3 polyunsaturated fatty acids (ω-3 PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to have cardioprotective and antiatherosclerotic actions. While it has been proposed that ω-3 ...