Now showing items 1-4 of 4

  • Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis. 

    Ibie, Chidinma O. (The Robert Gordon University School of Pharmacy and Life Sciences, 2010-10)
    Modified release multiparticulate pellets have been produced by the process of extrusion and spheronisation for colon-targeted delivery of cystamine, a cysteamine derivative. Orally ingested cysteamine formulations used ...
  • In-vitro evaluation of the effect of polymer structure on uptake of novel polymer-insulin polyelectrolyte complexes by human epithelial cells. 

    Ibie, Chidinma O.; Knott, Rachel M.; Thompson, Colin J. (Elsevier https://doi.org/10.1016/j.ijpharm.2014.12.058, 2014-12-27)
    IBIE, C., KNOTT, R. and THOMPSON, C.J. 2015. In-vitro evaluation of the effect of polymer structure on uptake of novel polymer-insulin polyelectrolyte complexes by human epithelial cells. International journal of pharmaceutics [online], 479(1), pages 103-117. Available from: https://doi.org/10.1016/j.ijpharm.2014.12.058
    The biocompatibility and cellular uptake of polymer, insulin polyelectrolyte complexes (PECs) prepared using polyallylamine-based polymers was evaluated in-vitro using Caco-2 cell monolayers as a predictive model for human ...
  • Novel polyelectrolyte complexes for oral insulin delivery. 

    Ibie, Chidinma O. (Robert Gordon University School of Pharmacy and Life Sciences, 2013-11)
    Oral delivery of insulin used for the management of Type 1 Diabetes could be referred to as one of the major long term goals of diabetes research. However, the bioavailability of orally administered insulin is significantly ...
  • Synthesis, characterisation and in vitro evaluation of novel thiolated derivatives of polyallylamine and quaternised polyallylamine. 

    Ibie, Chidinma O.; Thompson, Colin J.; Knott, Rachel M. (Springer https://doi.org/10.1007/s00396-015-3561-4, 2015-03-24)
    IBIE, C.O., THOMPSON, C.J. and KNOTT, R. 2015. Synthesis, characterisation and in vitro evaluation of novel thiolated derivatives of polyallylamine and quaternised polyallylamine. Colloid and polymer science [online], 293(6), pages 1737-1748. Available from: https://doi.org/10.1007/s00396-015-3561-4
    Polyallylamine (Paa) was quaternised by methylation of its primary amines using methyl iodide to yield quaternised Paa (QPaa). Average level of polymer quaternisation was determined by elemental analysis and was found to ...