Now showing items 1-9 of 9

  • Control of surface interactions with ultra-violet/ozone modification at polystyrene surface. 

    Liang, He (Robert Gordon University School of Engineering, 2014-01)
    Surface interactions and reactivity are of critical importance in current biomedical technologies, for example, satisfactory cell attachment and long term viability are essential for optimal in vitro tissue culture and for ...
  • Cytochrome P450 mRNA profile in human breast cancer cell lines 

    Warasiha, Benjamart (The Robert Gordon University School of Pharmacy and Life Sciences, 2008-05)
    Cytochrome P450 enzymes (P450s) are involved in cancer development and treatment due to their roles in the oxidative metabolism of various endogenous (e.g. oestrogen) and exogenous (e.g. tamoxifen) compounds. It is well-known ...
  • Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells. 

    Weidmann, Anita Elaine (Robert Gordon University School of Pharmacy and Life Sciences, 2008-03)
    Chronic complications of diabetes mellitus are a pathological consequence of unregulated levels of blood glucose leading to disorders of the vascular system. When investigating the vascular complications the changes in ...
  • The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies. 

    Gadad, Pramod C. (The Robert Gordon University School of Pharmacy and Life Sciences, 2011-01)
    Increased levels of blood glucose are associated with the vascular complications of diabetes. Microvascular complications lead to delayed wound healing in patients suffering from diabetes. Hypoxia and hyperglycaemia ...
  • Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells. 

    Hector, Emma E. (Robert Gordon University School of Pharmacy and Life Sciences., 2007-02)
    Poorly controlled diabetes mellitus is associated with the development of chronic vascular complications which cause morbidity and premature mortality. Many studies have highlighted maintenance of normal blood glucose ...
  • Novel polyelectrolyte complexes for oral insulin delivery. 

    Ibie, Chidinma O. (Robert Gordon University School of Pharmacy and Life Sciences, 2013-11)
    Oral delivery of insulin used for the management of Type 1 Diabetes could be referred to as one of the major long term goals of diabetes research. However, the bioavailability of orally administered insulin is significantly ...
  • Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis. 

    McKenzie, Barbara; Kay, Graeme; Matthews, Kerr H.; Knott, Rachel M.; Cairns, Donald (Elsevier https://doi.org/10.1016/j.ijpharm.2016.10.044, 2016-10-19)
    MCKENZIE, B., KAY, G., MATTHEWS, K.H., KNOTT, R. and CAIRNS, D. 2016. Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis. International journal of pharmaceutics [online], 515(1-2), pages 575-582. Available from: https://doi.org/10.1016/j.ijpharm.2016.10.044
    Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all organs. It is treated by regular administration of the aminothiol, cysteamine. Corneal ...
  • Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes. 

    Al Ali, Fatima Mohamed (Robert Gordon University Faculty of Health and Social Care. School of Pharmacy and Life Sciences., 2016-01)
    AL ALI, F.M. 2016. Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes. Robert Gordon University, MRes thesis.
    Diabetes mellitus (DM) is the most common metabolic disease worldwide. This condition accounts for the majority of renal failure and blindness in adult’s aged between 20 to 74 years of age. After 20 years, some of type 1 ...
  • Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. 

    Skene, Karen E. (The Robert Gordon University School of Pharmacy and Life Sciences., 2010-04)
    Neointimal formation is a complex process that occurs due to the over compensatory healing response produced by the vessel following injury. Three key events, SMC proliferation, SMC migration and the inflammatory response, ...