Now showing items 3-7 of 7

  • Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells. 

    Weidmann, Anita Elaine (Robert Gordon University School of Pharmacy and Life Sciences, 2008-03)
    Chronic complications of diabetes mellitus are a pathological consequence of unregulated levels of blood glucose leading to disorders of the vascular system. When investigating the vascular complications the changes in ...
  • The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies. 

    Gadad, Pramod C. (The Robert Gordon University School of Pharmacy and Life Sciences, 2011-01)
    GADAD, P. C., MOIR, D. and KNOTT, R. M., 2009. The effect of hypoxia and hyperglycemia on migration of microvascular endothelial cells. 45th EASD meeting. 29th September - 2nd October 2009. Diabetologie, 52, Suppl. 1, pp. S496
     
    GADAD, P. C., MATTHEWS, K. H. and KNOTT, R. M., 2010. Effect of lyophilised wafer discs containing silymarin on the migration of microvascular endothelial cells. UK-PharmSci 2010 - The Science of Medicine. 1-3 September 2010. Journal of Pharmacy and Pharmacology, 62 (10), pp. 1264
     
    Increased levels of blood glucose are associated with the vascular complications of diabetes. Microvascular complications lead to delayed wound healing in patients suffering from diabetes. Hypoxia and hyperglycaemia ...
  • Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells. 

    Hector, Emma E. (Robert Gordon University School of Pharmacy and Life Sciences., 2007-02)
    Poorly controlled diabetes mellitus is associated with the development of chronic vascular complications which cause morbidity and premature mortality. Many studies have highlighted maintenance of normal blood glucose ...
  • Novel polyelectrolyte complexes for oral insulin delivery. 

    Ibie, Chidinma O. (Robert Gordon University School of Pharmacy and Life Sciences, 2013-11)
    Oral delivery of insulin used for the management of Type 1 Diabetes could be referred to as one of the major long term goals of diabetes research. However, the bioavailability of orally administered insulin is significantly ...
  • Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. 

    Skene, Karen E. (The Robert Gordon University School of Pharmacy and Life Sciences., 2010-04)
    MARKOS, R., RUANE-O'HORA, T., SNOW, H. M., KELLY, R., WAINWRIGHT, C. L., SKENE, K., DRAKE-HOLLAND, A. J. and NOBLE, M. I., 2008. Dilation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig. Acta Physiologica, 194, pp. 207-213.
     
    SKENE, K., CRUICKSHANK, S., KNOTT, R., PERTWEE, R. and WAINWRIGHT, C. L., 2009. Studies on endocannabinoids and neointimal proliferation in an in vitro murine model. Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference 2009, 29, pp. e9-e130.
     
    SKENE, K., HECTOR, E., CRUICKSHANK, S., PERTWEE, R. and WAINWRIGHT, C. L., 2008. Characterisation of the response produced by AEA in the murine carotid artery and effects of cannabinoids on ERK1/2 phosphorylation. 18th Annual Symposium of the International Cannabinoid Research Society, p. 87.
     
    SKENE, K., STEWART, C., MIDDLETON, D., PERTWEE, R. and WAINWRIGHT, C. L., 2006. Studies on the receptors mediating relaxant responses to the endocannabinoid anandamide in the porcine coronary artery. 16th Annual Symposium of the International Cannabinoid Research Society, p. 173.
     
    Neointimal formation is a complex process that occurs due to the over compensatory healing response produced by the vessel following injury. Three key events, SMC proliferation, SMC migration and the inflammatory response, ...