Now showing items 1-12 of 12

  • Antimicrobial wafers as a novel technology for infection control in chronic wounds. 

    Labovitiadi, Olga (Robert Gordon University School of Pharmacy and Life Sciences, 2011)
    Bacterial contamination and persistent infection is a common cause of impaired wound healing. Generally, non-healing wounds display similar physiological features with regards to mixed bacterial flora, ischemia and production ...
  • Characterisation of illicit ecstasy and diazepam tablets by colorant identification. 

    Sharrenbroch, L.; Tough, Ann; Matthews, Kerr H. (Royal Society of Chemistry https://doi.org/10.1039/c7ay02921g, 2018-04-28)
    SHARRENBROCH, L., TOUGH, A. and MATTHEWS, K.H. 2018. Characterisation of illicit ecstasy and diazepam tablets by colorant identification. Analytical methods [online], 10(17), pages 2048-2055. Available from: https://doi.org/10.1039/c7ay02921g
    Ecstasy and diazepam are two commonly abused drugs with a high potential for dependence. They are typically available as oral tablets that contain both the drug and other bulk components (excipients). Compositional knowledge ...
  • Colistin causes profound morphological alteration but minimal cytoplasmic membrane perforation in populations of Escherichia coli and Pseudomonas aeruginosa. 

    O'Driscoll, Noelle H.; Cushnie, T. P. Tim; Matthews, Kerr H.; Lamb, Andrew (Springer https://doi.org/10.1007/s00203-018-1485-3, 2018-02-08)
    O'DRISCOLL, N.H., CUSHNIE, T.P.T., MATTHEWS, K.H. and LAMB, A.J. 2018. Colistin causes profound morphological alteration but minimal cytoplasmic membrane perforation in populations of Escherichia coli and Pseudomonas aeruginosa. Archives of microbiology [online], First Online. Available from: https://doi.org/10.1007/s00203-018-1485-3
    Whilst colistin (polymyxin E) represents the last mainstream treatment option for multi-drug resistant Gram-negative pathogens, details of its mechanism of action remain to be fully resolved. In this study, the effects ...
  • Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis. 

    Ibie, Chidinma O. (The Robert Gordon University School of Pharmacy and Life Sciences, 2010-10)
    Modified release multiparticulate pellets have been produced by the process of extrusion and spheronisation for colon-targeted delivery of cystamine, a cysteamine derivative. Orally ingested cysteamine formulations used ...
  • Examination of the antibacterial activities of some semi-synthetic chalcone-derivatives alone and in combination with polymyxin B. 

    Medu, Erere Ohwofasa (Robert Gordon University School of Pharmacy and Life Sciences, 2013-05)
    In view of the increasing global challenge of bacterial resistance, there exists an urgent need for the rationale development of antibacterial compounds with either novel or multiple mechanisms of action. Two chalcone-derivatives, ...
  • Formulation studies on cysteamine for the treatment of nephropathic cystinosis. 

    Buchan, Barbara Elizabeth (Robert Gordon University School of Pharmacy and Life Sciences, 2011-08)
    Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of almost all organs. It is treated by regular oral and topical administration of the aminothiol, ...
  • Investigation into the antimicrobial activity of cationic antibacterials. 

    O'Driscoll, Noelle H. (Robert Gordon University School of Pharmacy and Life Sciences, 2011-08)
    The topic addressed by the 2011 WHO‘s World Health Day was antibacterial resistance. This action served to highlight the serious problem bacterial resistance now presents to healthcare professionals globally. This investigation ...
  • The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies. 

    Gadad, Pramod C. (The Robert Gordon University School of Pharmacy and Life Sciences, 2011-01)
    Increased levels of blood glucose are associated with the vascular complications of diabetes. Microvascular complications lead to delayed wound healing in patients suffering from diabetes. Hypoxia and hyperglycaemia ...
  • A novel polyelectrolyte complex between amphiphilic poly (allyl amine) and sodium alginate. 

    Sartawi, Ziad (Robert Gordon University School of Pharmacy and Life Sciences, 2015-06)
    Polyelectrolytes are charge carrying polymers, when two oppositely charged polyelectrolytes are combined in a solution favouring charge expression, a polyelectrolyte complex can result. These complexes have been shown to ...
  • Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis. 

    McKenzie, Barbara; Kay, Graeme; Matthews, Kerr H.; Knott, Rachel M.; Cairns, Donald (Elsevier https://doi.org/10.1016/j.ijpharm.2016.10.044, 2016-10-19)
    MCKENZIE, B., KAY, G., MATTHEWS, K.H., KNOTT, R. and CAIRNS, D. 2016. Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis. International journal of pharmaceutics [online], 515(1-2), pages 575-582. Available from: https://doi.org/10.1016/j.ijpharm.2016.10.044
    Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all organs. It is treated by regular administration of the aminothiol, cysteamine. Corneal ...
  • A preliminary investigation to group disparate batches of licit and illicit diazepam tablets using differential scanning calorimetry. 

    Bibi, Shahdia; Bremner, D. H.; Macdougall-Heasman, M.; Reid, R.; Simpson, K.; Tough, Ann; Waddell, Stuart; Stewart, I. J.; Matthews, Kerr H. (Royal Society of Chemistry http://dx.doi.org/10.1039/C5AY01711D, 2015-10)
    BIBI, S., BREMNER, D. H., MACDOUGALL-HEASMAN, M., REID, R., SIMPSON, K., TOUGH, A., WADDELL, S., STEWART, I. J. and MATTHEWS, K. H., 2015. A preliminary investigation to group disparate batches of licit and illicit diazepam tablets using differential scanning calorimetry. Analytical Methods, 2015, 7, pp. 8597-8604.
    Increasing numbers of illicit and unlicensed medicines are in general circulation and regularly seized by the police and other regulatory authorities. Forensic identification of seized tablets tends to focus on ...
  • Suppository formulations as a potential treatment for nephropathic cystinosis. 

    McKenzie, Barbara; Kay, Graeme; Matthews, Kerr H.; Cairns, Donald (Elsevier https://doi.org/10.1002/jps.23246, 2012-07-06)
    BUCHAN, B., KAY, G., MATTHEWS, K.H. and CAIRNS, D. 2012. Suppository formulations as a potential treatment for nephropathic cystinosis. Journal of pharmaceutical sciences [online], 101(10), pages 3729-2738. Available from: https://doi.org/10.1002/jps.23246
    Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all the organs. It is treated by the 6-h oral administration of the aminothiol, cysteamine, ...