Now showing items 5-8 of 8

  • Pharmacological profiling of the hemodynamic effects of cannabinoid ligands: a combined in vitro and in vivo approach. 

    Walsh, Sarah K.; Hepburn, Claire Y.; Keown, Oliver; Astrand, Annika; Lindblom, Anna; Ryberg, Erik; Hjorth, Stephan; Leslie, Stephen J.; Greasley, Peter J.; Wainwright, Cherry L. (John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. http://dx.doi.org/10.1002/prp2.143, 2015-06)
    WALSH, S. K., HEPBURN, C. Y., KEOWN, O., ASTRAND, A., LINDBLOM, A., RYBERG, E., HJORTH, S., LESLIE, S. J., GREASLEY, P. J. and WAINWRIGHT, C. L., 2015. Pharmacological profiling of the hemodynamic effects of cannabinoid ligands: a combined in vitro and in vivo approach. Pharmacology Research & Perspectives, [online] 3 (3), article 143. Available from: http://onlinelibrary.wiley.com/doi/10.1111/prp2.2015.3.issue-3/issuetoc [Accessed 9 July 2015]
    The receptors mediating the hemodynamic responses to cannabinoids are not clearly defined due to the multifarious pharmacology of many commonly used cannabinoid ligands. While both CB1 and TRPV1 receptors are implicated, ...
  • Studies investigating the mechanisms of the cardioprotective effects of Cannabidiol. 

    Hepburn, Claire Y. (Robert Gordon University School of Pharmacy and Life Sciences., 2014-05)
    The phytocannabinoid cannabidiol (CBD) has a complex pharmacology which is thought to include, but is not limited to, an ability to act as an inverse agonist at the CB1 and CB2 receptors and an antagonist of GPR55. Moreover, ...
  • Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. 

    Skene, Karen E. (The Robert Gordon University School of Pharmacy and Life Sciences., 2010-04)
    Neointimal formation is a complex process that occurs due to the over compensatory healing response produced by the vessel following injury. Three key events, SMC proliferation, SMC migration and the inflammatory response, ...
  • Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid - possible role for endocannabinoids? 

    Michel, Lisa (Robert Gordon University School of Pharmacy and Life Sciences, 2012-05)
    The ω-3 polyunsaturated fatty acids (ω-3 PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to have cardioprotective and antiatherosclerotic actions. While it has been proposed that ω-3 ...