Now showing items 1-3 of 3

  • Activity of bisnaphthalimidopropyl derivatives agains trypanosoma brucei. 

    Graca, Nuno A.G.; Gaspar, Luis; Costa, David M.; Loureiro, Ines; Kong Thoo Lin, Paul; Ramos, Isbaal; Roura, Meritxell; Pruvost, Alain; Pemberton, Ian K.; Loukil, Hadjer; MacDougall, Jane; Tavares, Joana; Cordeiro-da-Silva, Anabela (American Society for Microbiology https://dx.doi.org/10.1128/AAC.02490-15, 2016-01-19)
    GRACA, N.A.G., GASPAR, L, COSTA, D.M., LOUREIRO, I., KONG THOO-LIN, P., RAMOS, I., ROURA, M., PRUVOST, A., PEMBERTON, I.K., LOUKIL, H., MACDOUGALL, J., TAVARES, J. and CORDEIRO-DA-SILVA, A. 2016. Activity of bisnaphthalimidopropyl derivatives agains trypanosoma brucei. Antimicrobial agents and chemotherapy [online], 60(4), pages 2532-2536. Available from: https://dx.doi.org/10.1128/AAC.02490-15
    Current treatments for African trypanosomiasis are either toxic, costly, difficult to administer, or prone to elicit resistance. This study evaluated the activity of bisnaphthalimidopropyl (BNIP) derivatives against ...
  • Development and validation of HPLC method with fluorometric detection for quantification of bisnaphthalimidopropyldiaminooctane in animal tissues following administration in polymeric nanoparticles. 

    Segundo, Marcela A.; Abreu, Vera L.R.G.; Osório, Marcelo V.; Nogueira, Sonia; Kong Thoo Lin, Paul; Cordeiro-da-Silva, Anabela; Lima, Sofia A.C. (Elsevier http://dx.doi.org/10.1016/j.jpba.2015.12.033, 2015-12-22)
    SEGUNDO, M.A., ABREU, V.L.R.G., OSORIO, M.V., NOGUEIRA, S., KONG THOO LIN, P., CORDEIRO-DA-SILVA, A. and LIMA, S.A.C. 2015. Development and validation of HPLC method with fluorometric detection for quantification of bisnaphthalimidopropyldiaminooctane in animal tissues following administration in polymeric nanoparticles. Journal of pharmaceutical and biomedical analysis [online], 120, pages 290-296. Available from: http://dx.doi.org/10.1016/j.jpba.2015.12.033
    A simple, sensitive and specific high-performance liquid chromatography method for the quantification of bisnaphthalimidopropyldiaminooctane (BNIPDaoct), a potent anti-Leishmania compound, incorporated into poly(d,l-lact ...
  • Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease. 

    Gaspar, Luis; Coron, Ross P.; Kong Thoo Lin, Paul; Costa, David M.; Peres-Cabezas, Begona; Tavares, Joana; Roura-Ferrer, Meritxell; Ramos, Isbaal; Ronin, Celine; Major, Louise L.; Ciesielski, Fabrice; Pemberton, Ian K.; MacDougall, Jane; Ciapetti, Paola; Smith, Terry K.; Cordeiro-da-Silva, Anabela (Public Library of Science https://doi.org/10.1371/journal.pntd.0006180, 2018-01-22)
    GASPAR, L., CORON, R.P., KONG THOO LIN, P., COSTA, D.M., PERES-CABEZAS, B., TAVARES, J., ROURA-FERRER, M., RAMOS, I., RONIN, C., MAJOR, L.L., CIESIELSKI, F., PEMBERTON, I.K., MACDOUGALL, J., CIAPETTI, P., SMITH, T.K. and CORDEIRO-DA-SILVA, A. 2018. Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease. PLoS neglected tropical diseases [online], 12(1), article ID e0006180. Available from: https://doi.org/10.1371/journal.pntd.0006180
    Chagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region’s ...