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  • Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. 

    Barron, Gemma A.; Goua, Marie; Kuraoka, Isao; Bermano, Giovanna; Iwai, Shigenori; Lin, Paul Kong Thoo (Elsevier http://dx.doi.org/10.1016/j.cbi.2015.10.017, 2015-12-05)
    BARRON, G. A., GOUA, M., KURAOKA, I., BERMANO, G., IWAI, S. and LIN, P. K. T. L., 2015. Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. Chemico-Biological Interactions, Vol 242, pp. 307-315.
    Bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM) bisintercalates to DNA and is a potential anti-cancer therapeutic. In an attempt to elucidate the mechanism(s) underlying the potential of BNIPDaCHM; earlier ...
  • Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. 

    Barron, Gemma A. (The Robert Gordon University School of Pharmacy and Life Sciences, 2010-06)
    BARRON, G. A., BERMANO, G., GORDON, A. and LIN, Paul K. T., 2010. Synthesis, cytotoxicity and DNA-binding of novel bisnaphthalimidopropyl derivatives in breast cancer MDA-MB-231 cells. European Journal of Medicinal Chemistry, 45, pp. 1430-1437.
     
    BARRON, G., BERMANO, G., GORDON, A., RALTON, L. and KONG, T. L. P., 2006. The in vitro studies of novel Bis-naphthalimidopropyl polyamine derivatives against CaCO-2 cells. Poster presentation at Health Implications of Dietary Amines - a Joint COST Action 922 and Biochemical Society Focused Meeting (Biochemistry Society meeting), Aberdeen, UK, 19-21 October 2006.
     
    BARRON, G., BERMANO, G., GORDON, A. and LIN, P. K. T., 2008. Synthesis, cytotoxicity and DNA binding studies of novel Bisnaphthalimidopropyl polyamine derivatives (BNIPPs). Poster presentation at Industry Tours for Postgraduates (Royal Society of Chemistry), Edinburgh/Glasgow, UK, 16-18 March 2008 and 9th Tetrahedron Symposium challenges in Organic and Bioorganic Chemistry (Elsevier meeting), Berkeley, USA, 22-25 July 2008.
     
    The synthesis and characterisation of novel bisnaphthalimidopropyl polyamine (BNIPP) derivatives, has gained pace over the last couple of years, as they have enhanced aqueous solubility, without loss of biological activity, ...