Now showing items 2-4 of 4

  • Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling. 

    Weichhaus, Michael; Broom, John; Wahle, Klaus; Bermano, Giovanna (Spandidos Publications. http://dx.doi.org/10.3892/ol.2014.2085, 2014-07)
    WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G., 2014. Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling. Oncology Letters, 8 (1), pp. 374-378.
    Leptin is a hormone secreted by white fat tissue and signals the amount of overall body fat to the hypothalamus. The circulating concentration of leptin correlates with the level of obesity. Breast cancer risk is higher ...
  • Molecular aspects of the link between obesity, insulin resistance and breast cancer. 

    Weichhaus, Michael (The Robert Gordon University Centre for Obesity Research and Epidemiology (CORE), 2010-11)
    WEICHHAUS, M., BROOM, I. and BERMANO, G., 2010. The molecular contribution of TNF-alpha in the link between obesity and breast cancer. Oncology Reports (in press)
     
    WEICHHAUS, M., BROOM, I., WAHLE, K. and BERMANO, G., 2009. Insulin-induced gene expression changes in breast cancer cells and normal breast epithelial cells. Poster presented at 17th European Congress in Obesity (ECO) in Amsterdam. Obesity Facts, 2 (Suppl. 2 ), p. S172
     
    WEICHHAUS, M., BROOM, I., WAHLE, K. and BERMANO, G., 2008. Molecular aspects linking insulin resistance to breast cancer by activation of cell signalling pathways. Poster presented at 6th Annual World Congress on the Insulin Resistance Syndrome (WCIRS) in Los Angeles. Diabetes and Vascular Disease Research, 5 (3), P. 233
     
    WEICHHAUS, M., BROOM, I., WAHLE, K. and BERMANO, G., 2008. Molecular aspects of insulin resistance, cell signalling pathways and breast cancer in relation to obesity. Poster presented at the 16th European Congress on Obesity (ECO2008) in Geneva. International Journal of Obesity, 32 (Suppl. 1), P. S38
     
    WEICHHAUS, M., BROOM, I., WAHLE, K. and BERMANO, G., 2009. Effect of hypeinsulinaemia and impaired adipokines secretion on proliferation of human breast cancer and normal human breast epithelial cells. Oral presentation at the 5th Asia-Oceania Conference on Obesity (AOCO) in Mumbai. International Journal of Diabetes in Developing Countries, 28, P. S21
     
    Obesity is a multi-factorial metabolic disease, resulting in increased adipose tissue acquisition by the host. This disease increases the risk for developing co-morbidities, including Metabolic Syndrome and other disorders ...
  • Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. 

    Barron, Gemma A. (The Robert Gordon University School of Pharmacy and Life Sciences, 2010-06)
    BARRON, G. A., BERMANO, G., GORDON, A. and LIN, Paul K. T., 2010. Synthesis, cytotoxicity and DNA-binding of novel bisnaphthalimidopropyl derivatives in breast cancer MDA-MB-231 cells. European Journal of Medicinal Chemistry, 45, pp. 1430-1437.
     
    BARRON, G., BERMANO, G., GORDON, A., RALTON, L. and KONG, T. L. P., 2006. The in vitro studies of novel Bis-naphthalimidopropyl polyamine derivatives against CaCO-2 cells. Poster presentation at Health Implications of Dietary Amines - a Joint COST Action 922 and Biochemical Society Focused Meeting (Biochemistry Society meeting), Aberdeen, UK, 19-21 October 2006.
     
    BARRON, G., BERMANO, G., GORDON, A. and LIN, P. K. T., 2008. Synthesis, cytotoxicity and DNA binding studies of novel Bisnaphthalimidopropyl polyamine derivatives (BNIPPs). Poster presentation at Industry Tours for Postgraduates (Royal Society of Chemistry), Edinburgh/Glasgow, UK, 16-18 March 2008 and 9th Tetrahedron Symposium challenges in Organic and Bioorganic Chemistry (Elsevier meeting), Berkeley, USA, 22-25 July 2008.
     
    The synthesis and characterisation of novel bisnaphthalimidopropyl polyamine (BNIPP) derivatives, has gained pace over the last couple of years, as they have enhanced aqueous solubility, without loss of biological activity, ...