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  • Assessment of temporal dose-toxicity relationship of fumed silica nanoparticle in human lung A549 cells by conventional cytotoxicity and H-NMR-based extracellular metabonomic assays. 

    Irfan, Adeel; Cauchi, Michael; Edmands, William; Gooderham, Nigel J.; Njuguna, James; Zhu, Huijun (Oxford University Press on behalf of the Society of Toxicology. http://dx.doi.org/10.1093/toxsci/kfu009, 2014-04)
    IRFAN, A., CAUCHI, M., EDMANDS, W., GOODERHAM, N. J., NJUGUNA, J. and ZHU, H., 2014. Assessment of temporal dose-toxicity relationship of fumed silica nanoparticle in human lung A549 cells by conventional cytotoxicity and H-NMR-based extracellular metabonomic assays. Toxicological Sciences, 138 (2), pp. 354-364.
    As nanoparticles could form aggregates in biological systems, the dynamics of their dispersity drives the temporal effect of nanoparticles in vitro. To test this hypothesis, the fumed silica nanoparticles (SiNPs) that have ...