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dc.contributor.authorBarnett, Christopher M.
dc.contributor.authorLees, Martin R.
dc.contributor.authorCurtis, Anthony D. M.
dc.contributor.authorKong Thoo Lin, Paul
dc.contributor.authorCheng, Woei Ping
dc.contributor.authorHoskins, Clare
dc.date.accessioned2015-04-28T15:33:12Z
dc.date.available2015-04-28T15:33:12Z
dc.date.issued2013
dc.identifier.citationBARNETT, C. M., LEES, M. R., CURTIS, A. D. M., KONG THOO LIN, P., CHENG, W. P. and HOSKINS, C., 2013. Poly(allylamine) magnetomicelles for image guided drug delivery. Pharmaceutical Nanotechnology, 1 (3), pp. 224-238.en
dc.identifier.issn2211-7385en
dc.identifier.issn2211-7393en
dc.identifier.urihttp://hdl.handle.net/10059/1193
dc.description.abstractPolymeric micelles have received considerable interest for their use as drug delivery vehicles for hydrophobic drug solubilisation. Inorganic metallic nanoparticles have already been exploited clinically in diagnostics for their contrast ability, using magnetic resonance imaging. The combination of these two platforms results in a multifunctional drug carrier for image-guided drug delivery. Here we report the synthesis and evaluation of a new class of poly(allylamine) (PAA) polymer grafted with hydrophobic oxadiazole (Ox) pendant group in a 5% molar monomer: pendant ratio. Further, the thiol-containing pendant group facilitated the attachment of hybrid iron oxide-gold nanoparticles (HNPs) via dative covalent bonding. Physicochemical characterisation of both PAA-Ox5 and PAA-Ox5-HNP polymers was carried out using elemental analysis, nuclear magnetic resonance (NMR), fourier transform infrared spectroscopy (FTIR) and photon correlation spectroscopy (PCS). The drug loading potential of these novel aggregates was investigated, through direct conjugation of hydrophilic and encapsulation of hydrophobic drugs, respectively. The model hydrophobic drugs 2,6- diisopropylphenol (propofol) and (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'- cyclohex[2]ene]-3,4'-dione (griseofulvin), and the chemotherapeutic agents bisnapthalamidopropyldiaminooctane (BNIPDaoct) and 6-Thioguanine (6-TG) were used. The data showed that the addition of HNPs onto the PAA-Ox5 structure resulted in aggregates of 175 nm in diameter. The PAA-Ox5-HNP nano-aggregates were capable of high drug solubilisation capacities (25.79 mgmL-1, 1.68 mgmL-1 and 0.92 mgmL-1) for propofol, griseofulvin and BNIPDaoct, respectively. 6-TG was also successfully conjugated into the polymer structure (2.8 mgmL-1). In vitro assays on human pancreatic adenocarcinoma cells (BxPC-3) showed increased drug uptake and decreased IC50 values using the novel formulations compared with free drug. This study highlights the potential of PAA-Ox5-HNP as a bi-functional imaging and drug delivery platform.en
dc.description.sponsorshipThis work was funded by the Institute of Science and Technology in Medicine and the School of Pharmacy, Keele University. The NMR and ICP-OES analysis was carried out in the Lennard-Jones Laboratories in the School of Physical and Geographical Sciences. The magnetometer used in this research was obtained through the Science City Advanced Materials project: Creating and Characterizing Next Generation Advanced Materials project, with support from Advantage West Midlands (AWM) and part funded by the European Regional Development Fund (ERDF).en
dc.language.isoenen
dc.publisherBentham Scienceen
dc.relation.ispartofPharmaceutical Nanotechnology, Volume 1, Part 3en
dc.rightsCopyright : Bentham Science Publishers.en
dc.subjectAmphiphilic polymeren
dc.subjectDrug solubilisationen
dc.subjectHybrid nanoparticleen
dc.subjectImage guided drug deliveryen
dc.subjectMagnetomicelleen
dc.titlePoly(allylamine) magnetomicelles for image guided drug delivery.en
dc.typeJournal articlesen
dc.publisher.urihttp://dx.doi.org/10.2174/22117385113019990002en


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