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dc.contributor.authorBartlett, Carrie-Ann
dc.contributor.authorTaylor, Sarah
dc.contributor.authorFernandez, Carlos
dc.contributor.authorWanklyn, Ceri
dc.contributor.authorBurton, Daniel
dc.contributor.authorEnston, Emma
dc.contributor.authorRaniczkowska, Aleksandra
dc.contributor.authorBlack, Murdo
dc.contributor.authorMurphy, Lindy
dc.date.accessioned2016-04-19T10:35:00Z
dc.date.available2016-04-19T10:35:00Z
dc.date.issued2016-02-01
dc.identifier.citationBARTLETT, C-A., TAYLOR, S., FERNANDEZ, C., WANKLYN, C., BURTON, D., ENSTON, E., RANICZKOWSKA, A., BLACK, M. and MURPHY, L., 2016. Disposable screen printed sensor for the electrochemical detection of methamphetamine in undiluted saliva. Chemistry Central Journal, Vol 10 (3).en
dc.identifier.issn1752-153Xen
dc.identifier.urihttp://hdl.handle.net/10059/1443
dc.description.abstractBackground Methamphetamine has an adverse effect on the ability to drive safely. Police need to quickly screen potentially impaired drivers therefore a rapid disposable test for methamphetamine is highly desirable. This is the first proof-of-concept report of a disposable electrochemical test for methamphetamine in undiluted saliva. Results A screen printed carbon electrode is used for the N,N′-(1,4-phenylene)-dibenzenesulfonamide mediated detection of methamphetamine in saliva buffer and saliva. The oxidized mediator reacts with methamphetamine to give an electrochemically active adduct which can undergo electrochemical reduction. Galvanostatic oxidation in combination with a double square wave reduction technique resulted in detection of methamphetamine in undiluted saliva with a response time of 55 s and lower detection limit of 400 ng/mL. Conclusions Using a double square wave voltammetry technique, rapid detection of methamphetamine in undiluted saliva can be achieved, however there is significant donor variation in response and the detection limit is significantly higher than desired. Further optimization of the assay and sensor format is required to improve the detection limit and reduce donor effects.en
dc.language.isoenen
dc.publisherSpringeren
dc.rightshttps://creativecommons.org/licenses/by/4.0/en
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSquare wave voltammetryen
dc.subjectSWVen
dc.subjectGalvanostatic oxidationen
dc.subjectScreen printed electrodeen
dc.subjectMediatoren
dc.subjectMethamphetamineen
dc.subjectSalivaen
dc.subjectDetectionen
dc.titleDisposable screen printed sensor for the electrochemical detection of methamphetamine in undiluted saliva.en
dc.typeJournal articlesen
dc.publisher.urihttps://dx.doi.org/10.1186/s13065-016-0147-2en
refterms.accessExceptionNAen
refterms.depositExceptionNAen
refterms.panelUnspecifieden
refterms.technicalExceptionNAen
refterms.versionNAen
rioxxterms.typeJournal Article/Reviewen


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