Nutritional and methodological perspectives of zinc ions and complexes: physiological and pathological states.
Planells del Pozo, Elena
Florea, Daniela Ioana
Osso, Bartolome Quintero
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MOLINA-LOPEZ, J., PLANELLS DEL POZO, E., FLOREA, D.L., FERNANDEZ, C., OSSO, B.Q., ZALEWSKA, M., KRIZKOVA, S., HEGER, Z., KIZEK, R. and ADAM, V. 2016. Nutritional and methodological perspectives of zinc ions and complexes: physiological and pathological states. International journal of electrochemical science [online], 11, pages 4470-4496. Available from: http://dx.doi.org/10.20964/2016.06.38
Zinc, an essential element playing crucial roles in numerous physiciological but also phathological processes, is still one of the most studied elements. The main importance of this metal is especially based on the structural role of zinc ions in many proteins including the transaction factors, antioxidant enzymes and methalothioneins. Due to the role of zinc in many crucial physiological processes, its homeostasis must be intensively controlled. The controlling mechanisms are based especailly on the zinc transporters and low-molecular proteins metallothioneins (MT). Zinc deficiency has been related with different state of diseases. Here, we primarily aim our attention to zinc and nutrition reviewing the whole process from intake to determination of this metal. The function of zinc ions in proteins with particular emphasis to oxidative stress is discussed followed by intake mechanisms and the role of zinc ions in both physiological processes. Finally, we summarized the assays used for detection of zinc in complex biological matrices.