Show simple item record

dc.contributor.authorMcLay, James S.
dc.contributor.authorIzzati, Naila
dc.contributor.authorPallivalapila, Abdulrouf
dc.contributor.authorShetty, Ashalatha
dc.contributor.authorPande, Binita
dc.contributor.authorRore, Craig
dc.contributor.authorAl Hail, Moza
dc.contributor.authorStewart, Derek C.
dc.date.accessioned2018-01-05T09:47:13Z
dc.date.available2018-01-05T09:47:13Z
dc.date.issued2017-12-19en
dc.identifier.citationMCLAY, J.S., IZZATI, N., PALLIVALAPILA, A.R., SHETTY, A., PANDE, B., RORE, C., AL HAIL, M. and STEWART, D. 2017. Pregnancy, prescription medicines and the potential risk of herb-drug interactions: a cross-sectional survey. BMC complementary and alternative medicine [online], 17, article ID 543. Available from: https://doi.org/10.1186/s12906-017-2052-1en
dc.identifier.issn1472-6882en
dc.identifier.urihttp://hdl.handle.net/10059/2638
dc.description.abstractBackground: - Pregnant women are routinely prescribed medicines while self-medicating with herbal natural products to treat predominantly pregnancy related conditions. The aim of this study was to assess the potential for herb-drug interactions (HDIs) in pregnant women and to explore possible herb-drug interactions and their potential clinical significance. Methods: - A cross-sectional survey of women during early pregnancy or immediately postpartum in North-East Scotland. Outcome measures included; Prescription medicines use excluding vitamins and potential HDIs assessed using Natural Medicines Comprehensive Database. Results: - The survey was completed by 889 respondents (73% response rate). 45.3% (403) reported the use of at least one prescription medicine, excluding vitamins. Of those taking prescription medicines, 44.9% (181) also reported concurrent use of at least one HNP (Range 1-12). A total of 91 different prescription medicines were reported by respondents using HNPs. Of those taking prescription medicines, 44.9% (181) also reported concurrent use of at least one HNP (Range 1-12). Thirty-four herb-drug interactions were identified in 23 (12.7%) women with the potential to increase the risk of postpartum haemorrhage, alter maternal haemodynamics, and enhance maternal/fetal CNS depression. Almost all were rated as moderate (93.9%), one as a potentially major (ginger and nifedipine) and only one minor (ondansetron and chamomile). Conclusion: - Almost half of pregnant women in this study were prescribed medicines excluding vitamins and minerals and almost half of these used HNPs. Potential moderate to severe HDIs were identified in an eighth of the study cohort. Healthcare professionals should be aware that the concurrent use of HNPs and prescription medicines during pregnancy is common and carries potential risks.en
dc.description.sponsorshipUniversity of Aberdeen ; Robert Gordon University ; NHS Scotland ; Hamad Medical Corporation.en
dc.language.isoengen
dc.publisherBioMed Centralen
dc.rightshttps://creativecommons.org/licenses/by/4.0en
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHerbalen
dc.subjectBotanicalen
dc.subjectPregnancyen
dc.subjectHerb-drug interactionen
dc.subjectAntenatalen
dc.subjectPostnatalen
dc.subjectFemaleen
dc.subjectSurveys and questionnairesen
dc.titlePregnancy, prescription medicines and the potential risk of herb-drug interactions: a cross-sectional survey.en
dc.typeJournal articlesen
dc.publisher.urihttps://doi.org/10.1186/s12906-017-2052-1en
dcterms.dateAccepted2017-12-07en
dcterms.publicationdate2017-12-19en
refterms.accessExceptionNAen
refterms.dateDeposit2018-01-05en
refterms.dateFCA2017-12-19en
refterms.dateFCD2018-01-05en
refterms.dateFreeToDownload2017-12-19en
refterms.dateFreeToRead2017-12-19en
refterms.dateToSearch2017-12-19en
refterms.depositExceptionpublishedGoldOAen
refterms.panelAen
refterms.technicalExceptionNAen
refterms.versionVoRen
rioxxterms.publicationdate2017-12-19en
rioxxterms.typeJournal Article/Reviewen
rioxxterms.versionVoRen


Files in this item

This item appears in the following Collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0