Correlation between bacterial G+C content, genome size and G+C content of associated plasmids and bacteriophages.
McEwan, Neil R.
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AALMPANIS, A., SWAIN, M., GATHERER, D. and MCEWAN, N. 2018. Correlation between bacterial G+C content, genome size and G+C content of associated plasmids and bacteriophages. Microbial genomics [online], 4(4), article ID 168. Available from: https://doi.org/10.1099/mgen.0.000168
Based on complete bacterial genome sequence data, we demonstrate a correlation between bacterial chromosome length and G+C content of the genome, with longer genomes having higher G+C contents. The correlation value decreases at shorter genome sizes where there is a wider spread of G+C values. However although significant (p < 0.001) the correlation value (Pearson R = 0.58) suggests that other factors also have a significant influence. A similar pattern was seen for plasmids; longer plasmids had higher G+C values, although the large number of shorter plasmids had a wide spread of G+C values. There was also a significant (p < 0.0001) correlation between G+C content of plasmids and the G+C content of their bacterial host. Conversely, the G+C content of bacteriophages tended to reduce with larger genome sizes and although there was a correlation between host genome G+C content and that of bacteriophage it was not as strong as that seen between plasmids and their hosts.