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dc.contributor.authorLam, Thomas B. L.
dc.contributor.authorMacLennan, Steven
dc.contributor.authorPlass, Karin
dc.contributor.authorWillemse, Peter-Paul M.
dc.contributor.authorMason, Malcolm D.
dc.contributor.authorCornford, Philip
dc.contributor.authorDonaldson, James
dc.contributor.authorDavis, Niall F.
dc.contributor.authorDell'Oglio, Paolo
dc.contributor.authorFankhauser, Christian
dc.contributor.authorGrivas, Nikos
dc.contributor.authorIngels, Alexandre
dc.contributor.authorLardas, Michael
dc.contributor.authorLiew, Matthew
dc.contributor.authorPang, Karl H.
dc.contributor.authorPaterson, Catherine
dc.contributor.authorOmar, Muhammad I.
dc.contributor.authorZattoni, Fabio
dc.contributor.authorBuddingh, Karel Tim
dc.contributor.authorVan den Broeck, Thomas
dc.contributor.authorCumberbatch, Marcus G.
dc.contributor.authorFossati, Nicola
dc.contributor.authorGross, Tobias
dc.contributor.authorMoris, Lisa
dc.contributor.authorSchoots, Ivo G.
dc.contributor.authorvan den Bergh, Roderick C. N.
dc.contributor.authorBriers, Erik
dc.contributor.authorFanti, Stefano
dc.contributor.authorDe Santis, Maria
dc.contributor.authorGillessen, Silke
dc.contributor.authorGrummet, Jeremy P.
dc.contributor.authorHenry, Ann M.
dc.contributor.authorvan der Poel, Henk G.
dc.contributor.authorvan der Kwast, Theodorus H.
dc.contributor.authorRouvière, Olivier
dc.contributor.authorTilki, Derya
dc.contributor.authorWiegel, Thomas
dc.contributor.authorN'Dow, James
dc.contributor.authorVan Poppel, Hendrik
dc.contributor.authorMottet, Nicholas
dc.identifier.citationLAM, T.B.L., MACLENNAN, S., PLASS, K., WILLEMSE, P.-P.M., MASON, M.D., CORNFORD, P., DONALDSON, J., DAVIS, N.F., DELL'OGLIO, P., FANKHAUSER, C., GRIVAS, N., INGELS, A., LARDAS, M., LIEW, M., PANG, K.H., PATERSON, C., OMAR, M.I., ZATTONI, F., BUDDINGH, K.T., VAN DEN BROECK, T., CUMBERBATCH, M.G., FOSSATI, N., GROSS, T., MORIS, L., SCHOOTS, I.G., VAN DEN BERGH, R.C.N., BRIERS, E., FANTI, S., DE SANTIS, M., GILLESSEN, S., GRUMMET, J.P., HENRY, A.M., VAN DER POET, H.G., VAN DER KWAST, T.H., ROUVIÉRE, O., TILKI, D., WIEGEL, T., N'DOW, J., VAN POPPEL, H. and MOTTET, N. 2018. Study protocol for DETECTIVE study: an international collaborative study to develop consensus statements for deferred treatment with curative intent for localised prostate cancer. European urology [online], Articles in Press. Available from:
dc.description.abstractDeferred active treatment (DAT) strategies, including active surveillance and active monitoring, are a recognised management option for men with localised low-risk prostate cancer. However, there is uncertainty due to heterogeneity of patient selection criteria, follow-up and monitoring characteristics, reclassification thresholds, and which outcome measures should be prioritised. This protocol describes a study led by the European Association of Urology (EAU) Prostate Cancer Guidelines Panel in conjunction with other guideline organisations and societies to develop consensus statements for all domains of deferred active treatment. The project is divided into 3 sequential phases: (1) Systematic review of studies reporting on DAT in order to summarise and define range of heterogeneity regarding all domains; (2) Two-round Delphi online survey involving a large, international panel of healthcare professionals (HCPs) and patients to initiate consensus; and (3) Consensus group meeting involving representatives from HCP and patient stakeholder groups to finalise the consensus process. The consensus statements are expected to be adopted by clinical practice guidelines in order to standardise and guide practice for clinicians and researchers until better evidence emerges. Patient summary: We describe a project aimed at standardising elements of practice in active surveillance/monitoring for early localised prostate cancer, because currently there is great variation and uncertainty regarding how best to conduct them. This will be achieved through a structured process of agreement (i.e. consensus) amongst a large, international panel of healthcare professionals and patients.en
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.subjectDeferred active treatmenten
dc.subjectProstate canceren
dc.subjectClinical practice guidelinesen
dc.titleStudy protocol for DETECTIVE Study: An international collaborative study to develop consensus statements for deferred treatment with curative intent for localised prostate cancer.en
dc.typeJournal articlesen
rioxxterms.typeJournal Article/Reviewen

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