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|Title: ||High dimensional indexing for protein structure matching|
|Authors: ||Huang, Zi|
|Editors: ||Chen, Yi-Ping Phoebe|
|Keywords: ||Protein structures|
High dimensional indexing
|Issue Date: ||Jan-2005|
|Publisher: ||Imperial College Press.|
|Citation: ||HUANG, Z., ZHOU, X. and SONG, D., 2005. High dimensional indexing for protein structure matching. In: Y-P. P. CHEN and L. WONG eds. Proceedings of the 3rd Asia-Pacific Bioinformatics Conference. 17-21 January 2005. Singapore: Imperial College Press. pp. 21-30.|
|Abstract: ||For determining functionality dependencies between two proteins, both represented as 3D structures,
it is an essential condition that they have a matching structure. As 3D structures for proteins are large,
complex and constantly evolving, it is very time-consuming to identify possible locations and sizes
of such a matching structure for a given protein against a large protein database. In this paper, we
introduce a novel representation model and apply a transformation and formalization to this problem.
We then propose a database solution by using innovative high dimensional indexing mechanisms.
Experimental results demonstrate a promising performance of the high dimensional indexing to this
biologically critical but previously computationally prohibitive problem.|
|Appears in Collections:||Conference publications (Computing)|
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