Recent Submissions

  • Review: barriers to physical activity in obese adults: a rapid evidence assessment. 

    Broom, Iain (SAGE https://dx.doi.org/10.1177/1744987116647820, 2016-05-11)
    BROOM, I. 2016. Review: barriers to physical activity in obese adults: a rapid evidence assessment. Journal of research in nursing [online], 21(4), pages 288-289. Available from: https://dx.doi.org/10.1177/1744987116647820
    Obesity is clearly a major public health problem in developed nations, but also impacts on the health of developing countries, as they adopt lifestyle practices of the former. Physical activity, or lack of it, contributes ...
  • Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. 

    Barron, Gemma A.; Goua, Marie; Kuraoka, Isao; Bermano, Giovanna; Iwai, Shigenori; Kong Thoo Lin, Paul (Elsevier http://dx.doi.org/10.1016/j.cbi.2015.10.017, 2015-12-05)
    BARRON, G. A., GOUA, M., KURAOKA, I., BERMANO, G., IWAI, S. and LIN, P. K. T. L., 2015. Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. Chemico-Biological Interactions, Vol 242, pp. 307-315.
    Bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM) bisintercalates to DNA and is a potential anti-cancer therapeutic. In an attempt to elucidate the mechanism(s) underlying the potential of BNIPDaCHM; earlier ...
  • Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks. 

    Nikokavoura, Efsevia Anastasia; Johnston, Kelly L.; Broom, John; Wrieden, Wendy L.; Rolland, Catherine (Dove Medical Press http://dx.doi.org/10.2147/DMSO.S85134, 2015-10)
    NIKOKAVOURA, E. A., JOHNSTON, E. L., BROOM, J., WRIEDEN, W. L. and ROLLAND, C., 2015. Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2015:8, pp. 495-503.
    Background: Polycystic ovary syndrome (PCOS) affects between 2% and 26% of reproductive-age women in the UK, and accounts for up to 75% of anovulatory infertility. The major symptoms include ovarian disruption, hyperandrogenism, ...
  • Long-term weight loss maintenance and management following a VLCD: a 3-year outcome. 

    Rolland, Catherine; Johnston, Kelly L.; Lula, Sadiq; Macdonald, Ian; Broom, Iain (Wiley http://dx.doi.org/10.1111/ijcp.12300, 2014-03)
    ROLLAND, C., JOHNSTON, K. L., LULA, S., MACDONALD, I. and BROOM, I., 2014. Long-term weight loss maintenance and management following a VLCD: a 3-year outcome. International Journal of Clinical Practice, 68 (3), pp. 379-387.
    Background: Effective weight loss treatment is important as obesity has severe health and socioeconomic repercussions. Emerging evidence suggests that rapid initial weight loss results in better long-term weight loss ...
  • Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling. 

    Weichhaus, Michael; Broom, John; Wahle, Klaus; Bermano, Giovanna (Spandidos Publications. http://dx.doi.org/10.3892/ol.2014.2085, 2014-07)
    WEICHHAUS, M., BROOM, J., WAHLE, K. and BERMANO, G., 2014. Leptin inhibits proliferation of breast cancer cells at supraphysiological concentrations by inhibiting mitogen-activated protein kinase signaling. Oncology Letters, 8 (1), pp. 374-378.
    Leptin is a hormone secreted by white fat tissue and signals the amount of overall body fat to the hypothalamus. The circulating concentration of leptin correlates with the level of obesity. Breast cancer risk is higher ...
  • Weight loss for individuals with type 2 diabetes following a very-low-calorie diet in a community-based setting with trained facilitators for 12 weeks. 

    Rolland, Catherine; Lula, S.; Jenner, C.; Dyson, Lee; Macdonald, I.; Johnston, Kelly L.; Broom, Iain (Wiley. http://dx.doi.org/10.1111/cob.12029, 2013-10)
    ROLLAND, C., LULA, S., JENNER, C., DYSON, L., MACDONALD, I., JOHNSTON, K. L. and BROOM, I., 2013. Weight loss for individuals with type 2 diabetes following a very-low-calorie diet in a community-based setting with trained facilitators for 12 weeks. Clinical Obesity, 3 (5), pp. 150-157.
    Approximately 80% of people with type 2 diabetes mellitus (T2DM) are overweight or obese, and obesity compounds the cardiovascular risk of T2DM. The aim of this retrospective study was twofold: first to investigate whether ...
  • The effect of very-low calorie diets on renal and hepatic outcomes: a systematic review. 

    Rolland, Catherine; Mavroeidi, Alexandra; Johnston, Kelly L.; Broom, John (Dove Press. http://dx.doi.org/10.2147/DMSO.S51151, 2013-10)
    ROLLAND, C., MAVROEIDI, A., JOHNSTON, K. L. and BROOM, J., 2013. The effect of very-low calorie diets on renal and hepatic outcomes: a systematic review. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Volume 2013 (6), pp. 393-401.
    Very low-calorie diets (VLCDs) are an effective means by which to induce clinically significant weight loss. However, their acceptance by health care practitioners and the public is generally lower than that for other ...
  • The implementation of the Counterweight Programme in Scotland, UK. 

    Counterweight Project Team; Bell-Higgs, Anna E.; Brosnahan, Naomi T.; Clarke, Anne M.; Dow, Maria S. A.; Haynes, Sarah M.; Lyons, G. Felicity; McCombie, E. Louise; Mongia, Sarika; Noble, Paula A.; Quinn, Marney F.; Regan, Paula J.; Ross, Hazel M.; Thompson, Frances E.; Vermeulen, Adri; Broom, Iain; Reckless, John P. D.; Kumar, Sudhesh; Lean, Michael E. J.; Frost, Gary S.; Finer, Nick; Haslam, David W.; Morrison, David; Sloan, Billy; McLoone, Philip (Oxford University Press. http://dx.doi.org/10.1093/fampra/cmr074, 2012-04)
    COUNTERWEIGHT PROJECT TEAM, 2012. The implementation of the Counterweight Programme in Scotland, UK. Family Practice, 29 (Supp. 1), pp. i139-i144.
    Background. The Counterweight Programme is a proven model for the management of obesity in the UK, evaluated over 5 years (2000–05) and demonstrating clinical and cost effectiveness. The Scottish Government commissioned ...
  • Obesity and its health impact in Africa: a systematic review. 

    Adeboye, Bridget; Bermano, Giovanna; Rolland, Catherine (Clinics Cardive Publishing. http://dx.doi.org/10.5830/CVJA-2012-040, 2012-10)
    ADEBOYE, B., BERMANO, G. and ROLLAND, C., 2012. Obesity and its health impact in Africa: a systematic review. Cardiovascular Journal of Africa, 23 (9), pp. 512-521.
    Obesity and its association with co-morbidities in Africa are on the rise. This systematic review examines evidence of obesity and its association with co-morbidities within the African continent. Comparative studies ...
  • Optimizing acceptability and feasibility of an evidence-based behavioral intervention for obese adults with obesity-related co-morbidities or additional risk factors for co-morbidities: an open-pilot intervention study in secondary care. 

    Dombrowski, Stephan U.; Sniehotta, Falko F.; Johnston, Marie; Broom, Iain; Kulkarni, Utkarsh; Brown, Jennifer E.; Murray, Lynne; Soares, Vera A. (Elsevier. http://dx.doi.org/10.1016/j.pec.2011.08.003, 2012-04)
    DOMBROWSKI, S. U., SNIEHOTTA, F. F., JOHNSTON, M., BROOM, I., KULKARNI, U., BROWN, J., MURRAY, L., SOARES, V. A., 2012. Optimizing acceptability and feasibility of an evidence-based behavioral intervention for obese adults with obesity-related co-morbidities or additional risk factors for co-morbidities: an open-pilot intervention study in secondary care. Patient Education and Counseling, 87 (1), pp. 108-119.
    Objective To test and optimize the feasibility and acceptability of a physical activity (PA) and healthy eating behavior change intervention for obese adults with obesity-related co-morbidities or additional risk factors ...
  • Engaging patients, clinicians and health funders in weight management: the Counterweight Programme. 

    Counterweight Project Team; McQuigg, Maria; Brown, Jennifer E.; Broom, Iain; Laws, Rachel A.; Reckless, John P. D.; Noble, Paula A.; Kumar, Sudhesh; McCombie, E. Louise; Lean, Mike E. J.; Lyons, G. Felicity; Mongia, Sarika; Frost, Gary S.; Quinn, Marney F.; Barth, Julian H.; Haynes, Sarah M.; Finer, Nick; Haslam, David W.; Ross, Hazel M.; Hole, David J.; Radziwonik, Steven (Oxford University Press http://dx.doi.org/10.1093/fampra/cmn081, 2008-12)
    THE COUNTERWEIGHT PROJECT TEAM: MCQUIGG, M., BROWN, J. E., BROOM, J. I., LAWS, R. A., RECKLESS, J. P. D., NOBLE, P. A., KUMAR, S., MCCOMBIE, E. L., LEAN, M. E. J., LYONS, G. F., MONGIA, S., FROST, G. S., QUINN, M. F., BARTH, J. H., HAYNES, S. M., FINER, N., HASLAM, D. W., ROSS, H. M., HOLE, D. J., and RADZIWONIK, S., 3008. Engaging patients, clinicians and health funders in weight management: the Counterweight Programme. Family Practice, 25 (S1), pp. i79-i86.
    Background. The Counterweight Programme provides an evidence based and effective approach for weight management in routine primary care. Uptake of the programme has been variable for practices and patients. Aim. To explore ...
  • Weight loss and ethnicity: a cohort study of the effects induced by a very low calorie diet. 

    Rolland, Catherine; Hallam, Claire; Lula, Sadiq; Wiggins, John; Dyson, Lee; Van Gaal, Luc F.; Broom, Iain (Hikari Ltd. http://m-hikari.com/cems/cems2013/cems1-4-2013/rollandCEMS1-4-2013.pdf, 2012)
    ROLLAND, C., HALLAM, C., LULA, S., WIGGINS, J., DYSON, L., VAN GAAL, L. F. and BROOM, I., 2012. Weight loss and ethnicity: a cohort study of the effects induced by a very low calorie diet. Clinical and Experimental Medical Sciences, 1 (3), pp. 97-109.
    Background: We aimed to determine whether British Asians of Indian or Pakistani descent differed in their baseline characteristics and in response to a 12 week very low calorie diet (VLCD). We then assessed if changes ...
  • Thinking around abdominal obesity and cardiovascular risk. 

    Broom, Iain (SAGE Publications., 2006-03)
    BROOM, I., 2006. Thinking around abdominal obesity and cardiovascular risk. British Journal of Diabetes and Vascular Disease, 6 (2), pp. 58-61.
    Obesity, particularly abdominal (visceral) obesity, is a burden on healthcare systems worldwide and is a leading cause of cardiovascular disease (CVD), insulin resistance, Type 2 diabetes, dyslipidaemia, metabolic syndrome, ...
  • Over-the-counter Orlistat: early experiences, views and attitudes of community pharmacists in Great Britain. 

    Weidmann, Anita Elaine; Cunningham, Scott; Gray, Gwen; Hansford, Denise; McLay, James; Broom, John; Stewart, Derek C. (Springer Verlag http://dx.doi.org/10.1007/s11096-011-9516-z, 2011-08)
    WEIDMAN, A. E., CUNNINGHAM, S., GRAY, G., HANSFORD, D., MCLAY, J., BROOM, J. and STEWART, D., 2011. Over-the-counter Orlistat: early experiences, views and attitudes of community pharmacists in Great Britain. International Journal of Clinical Pharmacy, 33 (4), pp. 627-633.
    Objectives of the study To describe community pharmacists’ early experiences, views and attitudes with over-the-counter orlistat, 9 months post legal re-classification from November 2009 to January 2010. Setting 13,200 ...
  • Very-low-energy diets and morbidity: a systematic review of longer-term evidence. 

    Mulholland, Yvonne; Nicokavoura, Efsevia; Broom, John; Rolland, Catherine (Cambridge University Press http://dx.doi.org/10.1017/S0007114512001924, 2012-09)
    MULHOLLAND, Y., NICOKAVOURA, E., BROOM, J. and ROLLAND, C., 2012. Very-low-energy diets and morbidity: a systematic review of longer-term evidence. British Journal of Nutrition, 108 (5), pp. 832-851.
    Evidence from the literature supports the safe use of very-low-energy diets (VLED) for up to 3 months in supervised conditions for patients who fail to meet a target weight loss using a standard low-fat, reduced-energy ...
  • Weight loss and cholesterol lowering in the elderly. 

    Rolland, Catherine; Broom, Iain (Ocean Media Group. http://www.gerimed.co.uk/archive/detail/?id=336, 2010-04)
    ROLLAND, C. and BROOM, I., 2010. Weight loss and cholesterol lowering in the elderly. Geriatric Medicine: GM2 ; Heart and Diabetes, 40 (Supp. 4), pp. 27-36.
    Weight loss and cholesterol lowering in the elderly remains a controversial issue. Obesity is considered to be problematic as a result of associated dyslipidemia, cardiovascular disease and mortality. Diet, exercise, ...
  • Assessing the significance of ethnicity on VLCD induced weight loss and outcomes at 1 year follow up. 

    Rolland, Catherine; Mulholland, Yvonne; Hallam, C.; Lula, S.; Dyson, L.; Broom, Iain (Karger http://dx.doi.org/10.1159/000178128, 2012)
    ROLLAND, C., MULHOLLAND, Y., HALLAM, C., LULA, S., DYSON, L. and BROOM, I., 2012. Assessing the significance of ethnicity on VLCD induced weight loss and outcomes at 1 year follow up. Obesity Facts, 5 (S1), p. 94
  • A comparison of weight loss outcomes in Black and Caucasian women following a very-low calorie diet (VLCD). 

    Rolland, Catherine; Mulholland, Yvonne; Hallam, C.; Lula, S.; Dyson, L.; Broom, Iain (Karger http://dx.doi.org/10.1159/000178128, 2012)
    ROLLAND, C., MULHOLLAND, Y., HALLAM, C., LULA, S., DYSON, L. and BROOM, I., 2012. A comparison of weight loss outcomes in Black and Caucasian women following a very-low calorie diet (VLCD). Obesity Facts, 5 (S1), p. 94
  • Biochemical adaptations in early starvation: observations on sex difference. 

    Broom, John; Fleck, A.; Davidson, D. F.; Rosenburg, C.; Durnin, J. V. G. A. (Cambridge University Press. http://dx.doi.org/10.1079/PNS19780048, 1978-12)
    BROOM, J., FLECK, A., DAVIDSON, D. F., ROSENBURG, C. and DURNIN, J. V. G. A., 1978. Biochemical adaptations in early starvation: observations on sex difference. Proceedings of the Nutrition Society, 37 (3), pp. 92A.
  • A study of the time course of fructose-2, 6-bisphosphate production in a septic mouse model. 

    Hepburn, D.; Broom, John; Smith, D. J. (Cambridge University Press. http://dx.doi.org/10.1079/PNS19860044, 1986-02)
    HEPBURN, D., BROOM, J. and SMITH, D. J., 1986. A study of the time course of fructose-2, 6-bisphosphate production in a septic mouse model. Proceedings of the Nutrition Society, 45 (1), 33A.

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