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dc.contributor.authorRolland, Catherine
dc.contributor.authorMavroeidi, Alexandra
dc.contributor.authorJohnston, Kelly L.
dc.contributor.authorBroom, John
dc.date.accessioned2013-11-06T12:48:04Z
dc.date.available2013-11-06T12:48:04Z
dc.date.issued2013-10
dc.identifier.citationROLLAND, C., MAVROEIDI, A., JOHNSTON, K. L. and BROOM, J., 2013. The effect of very-low calorie diets on renal and hepatic outcomes: a systematic review. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Volume 2013 (6), pp. 393-401.en
dc.identifier.issn1178-7007en
dc.identifier.urihttp://hdl.handle.net/10059/894
dc.description.abstractVery low-calorie diets (VLCDs) are an effective means by which to induce clinically significant weight loss. However, their acceptance by health care practitioners and the public is generally lower than that for other nonsurgical weight loss methods. Whilst there is currently little evidence to suggest they have any detrimental effect on hepatic and renal health, data assessing these factors remain limited. We carried out a systematic review of the literature on randomized controlled trials that had a VLCD component and that reported outcomes for hepatic and renal health, published between January 1980 and December 2012. Cochrane criteria were followed, and eight out of 196 potential articles met the inclusion criteria. A total of 548 participants were recruited across the eight studies. All eight studies reported significant weight loss following the VLCD. Changes in hepatic and renal outcomes were variable but generally led to either no change or improvements in either of these. Due to the heterogeneity in the quality and methodology of the studies included, the effect of VLCDs on hepatic and renal outcomes remains unclear at this stage. Further standardized research is therefore required to fully assess the impact of VLCDs on these outcome measures, to better guide clinical practice.en
dc.description.sponsorshipLighterLife Ltd, UK.en
dc.language.isoenen
dc.publisherDove Press.en
dc.relation.ispartofDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2013 Number 6en
dc.rightsCopyright : Dove Press.en
dc.subjectObesityen
dc.subjectSystematic reviewen
dc.subjectLiveren
dc.subjectKidneyen
dc.subjectWeight lossen
dc.subjectHealthen
dc.subjectvery-low-calorie dieten
dc.titleThe effect of very-low calorie diets on renal and hepatic outcomes: a systematic review.en
dc.typeJournal articlesen
dc.publisher.urihttp://dx.doi.org/10.2147/DMSO.S51151en


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